We reference: Spaander, M.C.W., Zauber, A.G., Syngal, S. et al. Young-onset colorectal cancer. Nat Rev Dis Primers 9, 21 (2023). https://doi.org/10.1038/s41572-023-00432-7

In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50 years has increased, which is referred to as early-onset CRC or young-onset CRC (YO-CRC). YO-CRC is expected to account for 11% of colon cancers and 23% of rectal cancers by 2030. This trend is observed in different parts of the world and in both men and women. In 20% of patients with YO-CRC, a hereditary cancer syndrome is found as the underlying cause; however, in the majority of patients no genetic predisposition is present.